杂志名称：Journal of Controlled Release
影响因子：10.5
文章题目：A cerium single-atom catalyst enables targeted catalytic therapy for acute kidney injury via neutrophil hitchhiking
DOI: https://doi.org/10.1016/j.jconrel.2025.02.011
第一作者：Yinying Pu, Yangying Duan, Wenhao Li, Han Lin, Qiyue Li, Binxu Yin, Kun Zhang, Bangguo Zhou, Wencheng Wu
作者单位：
中国电子科技大学四川省人民医院四川医学科学院
中国科学院上海硅酸盐研究所
浙江大学医学院附属第一医院
引用YOBIBIO产品：
Calcein,4,6-diamidino-2-phenylindole (DAPI)
propidium iodide (PI)
fluorescein isothiocyanate (FITC)
Superior Fetal bovine serum（U11-020A)
cell counting Kit-8 (CCK-8)

文章摘要：
Reactive oxygen species (ROS) play a major role in driving acute kidney injury (AKI) by causing oxidative stress and triggering inflammatory responses. However, treatment of AKI with traditional nanomedicines is still challenging because of low ROS scavenging efficacy and poor inflammatory chemotactic. Herein, we have constructed a novel cerium single-atom catalyst (A-CeSACs) for AKI catalytic therapy which targets inflammation and mimics several enzymatic redox activities. After injection of A-CeSACs into AKI mice via tail vein, targeting damaged kidney sites is realized by hitchhiking neutrophils that naturally target sites of inflammation via chemotaxis. After entering the AKI inflammatory environment, A-CeSACs rapidly scavenge multiple ROS via the Ce3+/Ce4+ redox reaction, thus reducing the release of inflammatory factors. The designed A-CeSACs displayed remarkably catalytic therapy efficacy in glycerol-induced AKI mice models. Overall, the present study describes a novel therapeutic strategy for targeted AKI catalytic therapy that is also potentially applicable to other inflammation-related diseases.

活性氧 （ROS） 通过引起氧化应激和触发炎症反应，在驱动急性肾损伤 （AKI） 中起主要作用。然而，由于 ROS 清除效率低且炎症趋化性差，使用传统纳米药物治疗 AKI 仍然具有挑战性。在此，我们构建了一种用于 AKI 催化治疗的新型铈单原子催化剂 （A-CeSACs），它靶向炎症并模拟几种酶促氧化还原活性。通过尾静脉将 A-CeSACs 注射到 AKI 小鼠中后，通过搭便车中性粒细胞来实现靶向受损肾脏部位，中性粒细胞通过趋化性自然靶向炎症部位。进入 AKI 炎症环境后，A-CeSACs 通过 Ce3+/Ce4+ 氧化还原反应快速清除多个 ROS，从而减少炎症因子的释放。设计的 A-CeSACs 在甘油诱导的 AKI 小鼠模型中显示出显着的催化治疗效果。总体而言，本研究描述了一种靶向 AKI 催化治疗的新型治疗策略，该策略也可能适用于其他炎症相关疾病。