杂志名称：Advanced Materials
影响因子：27.4
文章题目：Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis
DOI: https://doi.org/10.1002/adma.202415543
第一作者：Penghao Ji, Shuwen Qiu, Junchao Huang, Liping Wang, Yuemei Wang, Peng Wu, Minfeng Huo, Jianlin Shi
作者单位：
上海第十人民医院
上海纳米催化医学前沿科学中心
生物医学工程与纳米科学研究所
同济大学医学院
中国科学院上海硅酸盐研究所
高性能陶瓷与超细结构国家重点实验室
引用YOBIBIO产品：
U96-9403R  Rabbit TNF-α ELISA kit
U96-9405R  Rabbit IL-6 ELISA kit
U96-9406R  Rabbit IL-10 ELISA kit

文章摘要：
Rheumatoid arthritis (RA) is a kind of inflammation homeostasis disorder that dysfunctions the joints. Clinically, medications against RA focus simply on mitigating the focal inflammation, without considering pro‐osteogenesis re‐modeling of the bone microenvironment. In the present work, 2D layered calcium disilicide nanoparticles (CSNs) are fabricated by facile aqueous exfoliation. The hydrolysis of CSNs produces anti‐oxidative H2, alkaline Ca(OH)2, and silica. These moieties play significant roles in anti‐oxidation, anti‐inflammation, and pro‐osteogenesis resulting in considerably better RA therapeutic consequences than anti‐inflammation alone. Hydrogen gas is validated to eliminate excessive hydroxyl radicals and regulate macrophage re‐polarization; the generated Ca(OH)2 can neutralize the acidic microenvironment and inhibit the osteoclast activity; and, the dissolved Ca2+ can effectively complex with phosphates to mineralize Ca3(PO4)2, promoting the osteogenesis of the focal joint. The multifunctional performances of CSNs are further confirmed in arthritic mouse and rabbit models, providing an advanced and robust therapeutic strategy against RA with high biocompatibility and clinical transformable promises.

类风湿性关节炎 （RA） 是一种使关节功能障碍的炎症稳态障碍。在临床上，针对 RA 的药物仅侧重于减轻局灶性炎症，而不考虑骨微环境的促成骨重塑。在本工作中，通过简单的水性剥离制备了 2D 层状二硅化钙纳米颗粒 （CSN）。CSN 的水解产生抗氧化 H2、碱性 Ca（OH）2 和二氧化硅。这些部分在抗氧化、抗炎和促成骨方面发挥重要作用，导致比单独抗炎更好的 RA 治疗效果。氢气经验证可消除过量的羟基自由基并调节巨噬细胞再极化;生成的 Ca（OH）2 可以中和酸性微环境并抑制破骨细胞活性;并且，溶解的 Ca2+ 可以有效地与磷酸盐络合，使 Ca3（PO4）2 矿化，促进局灶关节的成骨。CSN 的多功能性能在关节炎小鼠和兔模型中得到进一步证实，提供了一种先进而稳健的 RA 治疗策略，具有高生物相容性和临床可转化前景。