用于免疫代谢癌症治疗的光活化免疫刺激性纳米药物
杂志名称：Journal of the American Chemical Societ
影响因子：15.0
文章题目：Photoactivatable Immunostimulatory Nanomedicine for Immunometabolic Cancer Therapy
文献地址：https://doi.org/10.1021/jacs.2c07872
第一作者：Wencheng Wu, Yinying Pu, Bangguo Zhou, Yucui Shen, Shuang Gao, Min Zhou, Jianlin Shi
作者单位：
中国科学院上海陶瓷研究所高性能陶瓷与超细微结构国家重点实验室；
中国医学科学院上海纳米催化医学重大疾病专项治疗研究中心；
上海市第十人民医院医学超声科；
同济大学肿瘤防治中心超声研究与教育研究所；
同济大学医学院；
上海同济大学第四人民医院消化内镜中心
引用产品：
Phosphate buffer solution (PBS) 
Dulbecco's modified eagle medium (DMEM)
calcein, 4, 6-diamidino-2-phenylindole (DAPI)
propidium iodide (PI)
fluorescein isothiocyanate (FITC)  
cell counting Kit-8 (CCK-8) 
文章摘要：

A rationally designed immunostimulant (CC@SiO₂-PLG) with a photoactivatable immunotherapeutic function for synergetic tumor therapy is reported. This CC@SiO₂-PLG nanoplatform comprises catalase and a photosensitizer (Ce6) co-encapsulated in a silica capsule, to which an immunostimulant is conjugated through a reactive oxygen species-cleavable linker. After accumulating in tumor tissue, CC@SiO₂-PLG generates O₂ to relieve tumor hypoxia and promotes the production of singlet oxygen (¹O₂) upon laser irradiation, resulting in not only tumor destruction but also the release of tumor-associated antigens (TAAs). Simultaneously, the linker breakage by the photoproduced ¹O₂ leads to the remote-controlled release of conjugated indoleamine 2,3-dioxygenase (IDO) inhibitor from CC@SiO₂-PLG and consequent immunosuppressive tumor microenvironment reversion. The released TAAs in conjunction with the inhibition of the IDO-mediated tryptophan/kynurenine metabolic pathway induced a boosted antitumor immune response to the CC@SiO₂-PLG-mediated phototherapy. Therefore, the growth of primary/distant tumors and lung metastases in a mouse xenograft model was greatly inhibited, which was not achievable by phototherapy alone.