杂志名称：Advanced Science
影响因子：15.1
文章题目：Engineering Photothermal Catalytic CO2 Nanoreactor for Osteomyelitis Treatment by In Situ CO Generation
DOI：http://doi.org/10.1002/advs.202402256
第一作者：Fan Zhuang，Luxia Jing，Huijing Xiang，Cuixian Li，Beilei Lu，Lixia Yan，Jingjing Wang，Yu Chen，Beijian Huang
作者单位：
复旦大学附属中山医院
上海大学生命科学学院
温州市实验室上海大学温州研究所
上海材料研究所
引用YOBIBIO产品：
U96-1511E  Mouse IL-6 ELISA Kit
U96-3112E  Mouse TNF-α ELISA kit
U96-1494E  Mouse IL-1β ELISA Kit

文章摘要：
Photocatalytic carbon dioxide (CO2) reduction is an effective method for in vivo carbon monoxide (CO) generation for antibacterial use. However, the available strategies mainly focus on utilizing visible-light-responsive photocatalysts to achieve CO generation. The limited penetration capability of visible light hinders CO generation in deep-seated tissues. Herein, a photothermal CO2 catalyst (abbreviated as NNBCs) to achieve an efficient hyperthermic effect and in situ CO generation is rationally developed, to simultaneously suppress bacterial proliferation and relieve inflammatory responses. The NNBCs are modified with a special polyethylene glycol and further embellished by bicarbonate (BC) decoration via ferric ion-mediated coordination. Upon exposure to 1064 nm laser irradiation, the NNBCs facilitated efficient photothermal conversion and in situ CO generation through photothermal CO2 catalysis. Specifically, the photothermal effect accelerated the decomposition of BC to produce CO2 for photothermal catalytic CO production. Benefiting from the hyperthermic effect and in situ CO production, in vivo assessments using an osteomyelitis model confirmed that NNBCs can simultaneously inhibit bacterial proliferation and attenuate the photothermal effect-associated pro-inflammatory response. This study represents the first attempt to develop high-performance photothermal CO2 nanocatalysts to achieve in situ CO generation for the concurrent inhibition of bacterial growth and attenuation of inflammatory responses.

光催化二氧化碳(CO2)还原是一种有效的抑菌用体内一氧化碳(CO)生成方法。然而，现有的策略主要集中在利用可见光响应的光催化剂来实现CO的生成。可见光有限的穿透能力阻碍了深层组织中CO的产生。本研究合理开发一种光热CO2催化剂(简称NNBCs)，实现高效的高温效应和原位CO生成，同时抑制细菌增殖和缓解炎症反应。nnbc用一种特殊的聚乙二醇修饰，并通过铁离子介导的配位用碳酸氢盐(BC)修饰。在1064 nm激光照射下，NNBCs通过光热CO2催化促进了高效的光热转化和原位CO生成。具体来说，光热效应加速了BC分解生成CO2，用于光热催化CO生产。得益于高温效应和原位CO生成，使用骨髓炎模型的体内评估证实，nnbc可以同时抑制细菌增殖并减弱光热效应相关的促炎反应。该研究首次尝试开发高性能光热CO2纳米催化剂，以实现原位CO生成，同时抑制细菌生长和减轻炎症反应。