杂志名称：Advanced Science
影响因子：14.3
文章题目：A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing
DOI：https://doi.org/10.1002/advs.202414161
第一作者：Bangguo Zhou, Yangying Duan, Wenhao Li, Tao Chen, Jincheng Wang, Manting Cao, Guohao Lin, Ke Yang, Zhangqi Lai, Wencheng Wu
作者单位：
四川医学科学院四川省人民医院中国电子科技大学
浙江大学医学院附属第一医院
浙江中医药大学第三临床医学院
引用YOBIBIO产品：
Calcein,4,6-diamidino-2-phenylindole (DAPI)
propidium iodide (PI)
fluorescein isothiocyanate (FITC)
Superior Fetal bovine serum（U11-020A)
cell counting Kit-8 (CCK-8)

文章摘要：
The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co-loading gold-cerium oxide (AuCeO2) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress-induced damage while exhibiting significant near-infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucose levels in the wound microenvironment, alleviating oxidative stress and inhibiting bacterial growth proliferation, thereby expediting the healing process. ACG gels demonstrated excellent wound healing-promoting properties in two in vivo wound models, providing a promising and effective platform for diabetic wound management.

慢性糖尿病伤口的管理是一项复杂的挑战，需要局部血糖调节、炎症水平调节和预防细菌感染。因此，开发了一种具有抗氧化、局部糖控制和抗菌特性的多功能伤口敷料，以促进糖尿病伤口愈合。该敷料是通过将氧化金铈 （AuCeO2） 哑铃和葡萄糖氧化酶 （GOx） 共同加载到活性氧 （ROS） 敏感的水凝胶基质 （ACG 凝胶） 中构建的。在该系统中，Au-CeO2 哑铃有效消除 ROS，保护细胞免受氧化应激诱导的损伤，同时表现出显着的近红外光热抗菌活性。此外，GOx 的受控释放可降低伤口微环境中的血糖水平，减轻氧化应激并抑制细菌生长增殖，从而加速愈合过程。ACG 凝胶在两种体内伤口模型中表现出优异的促进伤口愈合特性，为糖尿病伤口管理提供了一个有前途且有效的平台。