氢化硅纳米片制备水致氢高效抗炎
杂志名称：Journal of the American Chemical Societ
影响因子：15.0
文章题目：Water-Enabled H2 Generation from Hydrogenated Silicon Nanosheets for Efficient Anti-Inflammation
文献地址：https://doi.org/10.1021/jacs.2c04412
第一作者：Yanling You , Ya-Xuan Zhu , Junjie Jiang , Min Wang , Zhixin Chen , Chenyao Wu , Jie Wang , Wujie Qiu , Deliang Xu , Han Lin , Jianlin Shi 
作者单位：
中国科学院上海陶瓷研究所高性能陶瓷与超微结构国家重点实验室
中国医学科学院重大疾病特异性治疗纳米催化药物研究单位
上海市第十人民医院，
上海纳米催化医学前沿科学中心
同济大学医学院
中国科学院大学材料科学与光电子工程中心
上海中医药大学
引用产品：
Rat NGF Beta 生长因子β
Dulbecco’s modified eagle’s medium (DMEM, high glucose) DMEM高糖培养基
Roswell Park Memorial Institute (RPMI) 1640 medium RPMI 1640培养基
fetal bovine serum (FBS), PBS 胎牛血清
penicillin/streptomycin 青链霉素双抗

文章摘要：
As an emerging therapeutic gas, hydrogen (H2) is gifted with excellent biosafety, high tissue permeability, and radical-trapping capacity and is extensively considered as a highly promising antioxidant in clinics. However, a facile and effective strategy of H2 production for major inflammatory disease treatments is still lacking. In this study, by a facile wet-chemical exfoliation synthesis, a hydrogen-terminated silicon nanosheet (H-silicene) has been synthesized, which can favorably react with environmental water to generate H2 rapidly and continuously without any external energy input. Furthermore, theoretical calculations were employed to reveal the mechanism of enhanced H2 generation efficacy of H-silicene nanosheets. The as-synthesized H-silicene has been explored as a flexible hydrogen gas generator for efficient antioxidative stress application for the first time, which highlights a promising prospect of this two-dimensional H-silicene nanomaterial for acute inflammatory treatments by on-demand H2 production-enabled reactive oxygen species scavenging. This study provides a novel and efficient modality for nanomaterial-mediated H2 therapy.

作为一种新兴的治疗气体，氢气(H2)具有优异的生物安全性、高组织渗透性和自由基捕获能力，并被广泛认为是临床上非常有前途的抗氧化剂。然而，H2主要炎症疾病治疗药物的生产仍然缺乏。在本研究中，通过一种简单的湿化学剥离合成法，合成了氢封端的硅纳米片(H-硅烯),它可以很好地与环境水反应生成H2无需任何外部能量输入。此外，通过理论计算揭示了H增强的机理2H-硅烯纳米片的生成效率。首次探索了合成的H-硅烯作为有效抗氧化应激应用的柔性氢气发生器，这突出了这种二维H-硅烯纳米材料通过按需H2生产性活性氧清除。这项研究为纳米材料介导的氢原子转移提供了一种新颖有效的方式2治疗。